https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 A novel role for the TRAIL signalling pathway in the pathogenesis of Eosinophilic Oesophagitis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30505 Wed 11 Apr 2018 09:34:33 AEST ]]> In vivo targeting of miR-223 in experimental eosinophilic oesophagitis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41570 Thu 02 May 2024 15:43:27 AEST ]]> The outcome of patients with oesophageal eosinophilic infiltration after an eight-week trial of a proton pump inhibitor https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28581 Sat 24 Mar 2018 07:35:48 AEDT ]]> High-fat diet-induced obesity worsens TH2 immune response and immunopathologic characteristics in murine model of eosinophilic oesophagitis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40113 IL-5 and TSLP mRNA expression. In contrast, FoxP3 and IL-10 were less expressed in comparison with lean-allergic mice. In addition, the amount of CD11c+MHCII+PDL1+ dendritic cells was reduced, while the number of CD11c+MHCII+CD80+ DCs and CD3+CD4+GATA3+IL-4+ cells was increased in obese-allergic mice in the spleen and lymph nodes when compared to lean-allergic mice. Conclusion: Obesity aggravated the immune histopathological characteristics in the EoE experimental model, which was associated with the reduction in the regulatory profile, and the increased inflammatory cells influx, related to the TH2 profile. Altogether, the data provide new knowledge about obesity as a risk factor, worsening EoE symptoms, and contribute for future treatment strategies for this specific profile.]]> Fri 15 Jul 2022 09:55:49 AEST ]]>